Hydroxycitronellal-Indole (Schiff base) (CAS 68527-79-7) — Floral Heart Note Fragrance Ingredient
Hydroxycitronellal-Indole (Schiff base)
CAS 68527-79-7
What Is Hydroxycitronellal-Indole (Schiff base)?
Hydroxycitronellal-Indole is a sophisticated synthetic fragrance material created by perfumers. You’ll find it adding floral depth to high-end perfumes and luxury personal care products. This ingredient matters because it offers a unique balance of fresh citrus-floral tones with subtle animalic complexity, creating perfumes that evolve beautifully on skin.
Safety Profile
USE WITH AWARENESSWhat Does Hydroxycitronellal-Indole (Schiff base) Smell Like?
Hydroxycitronellal-Indole unfolds with a radiant citrus-floral burst reminiscent of magnolia blossoms dipped in morning dew. The initial brightness gradually reveals a plush heart of indolic jasmine, where clean white petals meet intimate animalic warmth. As it dries down, the scent transforms into a soft, powdery embrace with whispers of vanilla-like sweetness and a lingering skin-musk effect. This elegant metamorphosis from sparkling to sensual makes it a perfumer’s secret weapon for creating fragrances with both immediate appeal and lasting sophistication.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to create the signature magnolia-jasmine accord, adding luminous floralcy while preventing the composition from becoming overly sweet. Provides the ‘sunlit petals’ effect in the heart.
Modernizes the classic aldehydic bouquet by introducing a fresher floral dimension through hydroxycitronellal-indole’s bright yet complex character.
2D Molecular Structure
SMILES: CC(CCCC(C)(C)O)C=CN1C=CC2=CC=CC=C12
Chemistry, Properties & Perfumer Guide
The Chemistry
Hydroxycitronellal-Indole is a Schiff base formed through the condensation reaction between hydroxycitronellal and indole. This class of compounds is valued in perfumery for their stability and unique olfactory properties that differ from simple mixtures of the precursors. The reaction creates new molecular entities with modified volatility and scent profiles. While the exact structure of this specific Schiff base isn’t fully characterized in literature, similar compounds demonstrate enhanced floral character with reduced indole pungency.
Physical & Chemical Properties
| Appearance | Pale yellow to amber liquid |
|---|---|
| Solubility | Soluble in alcohol and oils |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-3% | Up to 5% | Floral heart note enhancer |
| Soap/Cosmetic | 0.5-1% | Up to 2% | Provides lasting floral character |
Classic Accords
Tip: Stabilize in ethanol before adding to oil-based formulations to prevent precipitation.
Alternatives & Comparisons
For cleaner floral effects without indolic complexity. Use when animalic facets aren’t desired.
When more pronounced jasmine-indole character is needed with less citrus-floral brightness.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted under IFRA standards, but usage may be limited by hydroxycitronellal content.
RIFM Assessment
Safety profile currently extrapolated from hydroxycitronellal and indole data. No dedicated RIFM assessment available.
Sustainability
As a synthetic material, hydroxycitronellal-indole offers consistent quality without plant sourcing pressures. Manufacturing requires controlled chemical processes with proper waste management. Being highly potent, it’s used in small quantities, reducing environmental load compared to some natural alternatives.
Explore Hydroxycitronellal-Indole (Schiff base)
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References
- Brenna et al. (2003). Schiff bases in perfumery. Flavour and Fragrance Journal.
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 68527-79-7Physical Properties
| Molecular Weight | 271.4 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 4.2🔬 PubChem |
| Boiling Point | 326 °C🔬 EPA CompTox |
| Vapor Pressure | 0 mmHg @ 25°C📊 OPERA |
| Flash Point | 195 °C🔬 EPA CompTox |
| log Kp (skin permeability) | -1.374💻 Calculated |
| SMILES | CC(CCCC(C)(C)O)C=CN1C=CC2=CC=CC=C21🔬 PubChem |
Volatility & Performance
| Fragrance Note | Base💻 Calculated |
Odor & Flavor
| Primary Descriptors | floralsweet• leffingwell |
| Functional Groups | alcoholalkenearomatic💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID30867663
Physical Properties
| Molecular Weight | 271.404 g/mol🔬 EPA CompTox |
| Density | 1.02 g/cm^3📊 OPERA |
| Boiling Point | 361.635 °C📊 OPERA |
| Melting Point | 108.964 °C📊 OPERA |
| Flash Point | 210.351 °C📊 OPERA |
| Refractive Index | 1.529 Dimensionless📊 OPERA |
| Molar Volume | 276.187 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 5.195 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 5.195 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 5.195 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 10.83 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0 mmHg📊 OPERA |
| Viscosity | 42.912 cP📊 OPERA |
| Surface Tension | 35.017 dyn/cm📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 25.16 Ų💻 Computed |
| H-Bond Donors | 1 count💻 Computed |
| H-Bond Acceptors | 2 count💻 Computed |
| Rotatable Bonds | 6 count💻 Computed |
| Aromatic Rings | 2 count💻 Computed |
| Molar Refractivity | 85.189 cm^3/mol📊 OPERA |
| Polarizability | 33.772 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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