Ethyl 2,4-dimethyldioxolane-2-acetate (CAS 6290-17-1) — Sweet Top to middle Note Fragrance Ingredient

ByThe Good Scents
Sweet · Green

Ethyl 2,4-dimethyldioxolane-2-acetate

CAS 6290-17-1

Origin
synthetic
Note
Top to middle
IFRA
Generally safe
Data as of: Apr 2026

What Is Ethyl 2,4-dimethyldioxolane-2-acetate?

Ethyl 2,4-dimethyldioxolane-2-acetate is a synthetic fragrance ingredient used to add fruity, green, and woody nuances to perfumes. It’s commonly found in modern fragrances seeking a fresh yet complex character. This molecule matters because it bridges fruity top notes with deeper woody accords, allowing perfumers to create seamless transitions in scent compositions.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ No major safety concerns reported
⚠ Limited toxicological data available
CAS
6290-17-1
Formula
Mixture
MW
Variable
Odor Family
Sweet · Green
Layer 1 · Enthusiast

What Does Ethyl 2,4-dimethyldioxolane-2-acetate Smell Like?

Ethyl 2,4-dimethyldioxolane-2-acetate opens with a crisp green apple peel freshness, quickly revealing a juicy pear-like fruitiness at its core. As it evolves, the scent develops woody undertones reminiscent of freshly split cedar, with a subtle herbal edge. The dry-down presents a clean, slightly musky character that lingers close to the skin. The overall effect is like biting into a just-ripe Bartlett pear while standing in a sun-dappled orchard, with the scent of warm wood and crushed green leaves in the air.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Eau de Rhubarbe Ecarlate(Hermès, 2016)

Used here to enhance the tart rhubarb note with its fruity-green character, creating a more dimensional fruity accord that bridges to the woody base.

Wood Sage & Sea Salt(Jo Malone, 2014)

Provides subtle fruity undertones to complement the herbal sage, adding complexity to the fresh coastal accord without overpowering the marine elements.

Layer 2

2D Molecular Structure

Ethyl 2,4-dimethyl-1,3-dioxolane-2-acetate

SMILES: CCOC(=O)CC1(C)OCC(C)O1

Chemistry, Properties & Perfumer Guide

The Chemistry

Ethyl 2,4-dimethyldioxolane-2-acetate belongs to the dioxolane ester class, synthesized through acid-catalyzed condensation of ethyl acetoacetate with butanediol. The molecule features a cyclic acetal structure that contributes to its stability and distinctive odor profile. The stereochemistry at the 2-position significantly impacts its olfactory characteristics, with different isomers exhibiting varying intensity of fruity notes.

Physical & Chemical Properties

AppearanceColorless to pale yellow liquid
Odor Threshold0.01 ppm in air

Perfumer Guide

Note Position
Top to middle
Volatility
Medium (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance0.5-2%Up to 5%Adds fruity-green complexity
Functional Fragrance0.1-0.5%Up to 1%Freshness booster

Classic Accords

Tip: Use in trace amounts with citrus oils to prevent masking their brightness.

Alternatives & Comparisons

1
Ethyl 2-methyl-4-propyl-1,3-oxathiane CAS 67715-80-4

Offers similar fruity-green character with greater tenacity and tropical nuances, useful when longer-lasting effects are desired.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA standards.

RIFM Assessment

Not currently evaluated by RIFM.

Sustainability

As a synthetic material, production can be optimized for minimal waste. No known ecological concerns regarding biodegradation. Sourcing avoids agricultural land use compared to natural alternatives.

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References

  1. Bauer, K. et al. (2001). Common Fragrance and Flavor Materials. Wiley-VCH.

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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Ingredient Data Sheet

CAS 6290-17-1

Physical Properties

Molecular Weight188.22 g/mol🔬 PubChem
LogP (Octanol-Water)0.7🔬 PubChem
Boiling Point214.4 °C🔬 EPA CompTox
Vapor Pressure0.0593 mmHg @ 25°C📊 OPERA
Flash Point90.5 °C🔬 EPA CompTox
Involatility Index0.0047💻 Calculated
log Kp (skin permeability)-3.351💻 Calculated
SMILESCCOC(=O)CC1(OCC(O1)C)C🔬 PubChem

Volatility & Performance

Fragrance NoteHeart💻 Calculated
Volatility ClassVery slow💻 Calculated
Persistence Score1.6 / 5💻 Calculated

Odor & Flavor

Primary Descriptorsapplefreshfruitystrawberrysweet• leffingwell
Functional Groupsesterether💻 RDKit
“This ketal type of chemical has found some use in perfume compositions where a ce~ain H3C\ / CHz-COO-C2H~ deep-fruity note is desirable along with a floral ‘c’ complex. Jasmin, Tuberose, Gardenia and /’ \ many other floral bases, spicy fragrances, etc. normally encouraged by a catalyst and carried Fruity-floral and warm, sweet odor of good out under conditions of azeotropic distillation.”📖 Arctander
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

Physicochemical Properties

DTXSID: DTXSID4047549

Physical Properties

Molecular Weight 188.223 g/mol🔬 EPA CompTox
Density 1.043 g/cm^3🔬 EPA CTX
Boiling Point 214.4 °C🔬 EPA CTX
Melting Point 13.637 °C📊 OPERA
Flash Point 90.5 °C🔬 EPA CTX
Refractive Index 1.424 Dimensionless📊 OPERA
Molar Volume 183.284 cm^3/mol📊 OPERA

Partition & Solubility

LogP (Octanol-Water) 1.8 Log10 unitless🔬 EPA CTX
LogD (pH 5.5) 0.988 Log10 unitless📊 OPERA
LogD (pH 7.4) 0.988 Log10 unitless📊 OPERA
LogKoa (Octanol-Air) 5.06 Log10 unitless📊 OPERA
Water Solubility 0.007 mol/L🔬 EPA CTX
Henry's Law Constant 0 atm-m3/mole📊 OPERA

Transport Properties

Vapor Pressure 0.059 mmHg🔬 EPA CTX
Viscosity 2.399 cP📊 OPERA
Surface Tension 31.788 dyn/cm📊 OPERA
Thermal Conductivity 131.486 mW/(m*K)📊 OPERA

Molecular Descriptors

Topological Polar Surface Area 44.76 Ų💻 Computed
H-Bond Donors 0 count💻 Computed
H-Bond Acceptors 4 count💻 Computed
Rotatable Bonds 3 count💻 Computed
Aromatic Rings 0 count💻 Computed
Molar Refractivity 46.734 cm^3/mol📊 OPERA
Polarizability 18.527 Å^3📊 OPERA

Data Sources:

🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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