(+)-cis-Rose oxide (CAS 4610-11-1) — Floral Top to middle Note Fragrance Ingredient
(+)-cis-Rose oxide
CAS 4610-11-1
What Is (+)-cis-Rose oxide?
(+)-cis-Rose oxide is a key molecule that gives roses their distinctive fresh, dewy character. You’ll find it in high-end perfumes and some floral-flavored gourmet foods. This compound matters because it captures the fleeting ‘just bloomed’ moment of roses that natural extracts can’t reliably reproduce.
Safety Profile
GENERALLY SAFEWhat Does (+)-cis-Rose oxide Smell Like?
The scent unfolds like morning sunlight hitting dew-covered roses – first a crisp green apple peel freshness, then the floral heart reveals itself with metallic lily-of-the-valley facets. Unlike common rose absolutes, this oxide carries a cooling minty undertone that prevents cloying sweetness. In drydown, it leaves a transparent aquatic trail reminiscent of rosewater ice cubes melting on hot stone.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used at 0.8% to create the illusion of freshly cut rose stems. The oxide’s green facets amplify the natural geranium note while preventing the rose absolute from becoming too jammy.
Provides the opening ‘rain on roses’ effect that distinguishes this from traditional rose perfumes. The cis isomer’s minty quality bridges the gap between rose and cumin notes.
2D Molecular Structure
SMILES: C[C@H]1CCO[C@H](C1)C=C(C)C
Chemistry, Properties & Perfumer Guide
The Chemistry
A monoterpene oxide with a stereocenter at carbon 2. The (+)-cis isomer occurs naturally in rose otto at ~0.5% concentration but is typically synthesized for perfumery via photooxygenation of citronellol. Chirality matters – the cis configuration delivers the desired fresh floral character while trans forms smell more herbal. Modern routes use singlet oxygen generated from hematoporphyrin under LED light to achieve >90% cis selectivity.
Physical & Chemical Properties
| Boiling Point | 70 °C at 0.1 mmHg |
|---|---|
| Density | 0.875 g/cm³ at 20°C |
| Refractive Index | 1.453 at 20°C |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.1-0.5% | Up to 1% | Rose reconstructions |
| Functional | 0.01-0.05% | Up to 0.1% | Fabric softeners |
Classic Accords
Tip: Add in the alcohol phase to prevent premature oxidation during maceration.
Alternatives & Comparisons
Firmer, more diffusive version with higher trans content for applications needing longer persistence.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No restrictions under IFRA 49th Amendment.
RIFM Assessment
Evaluated in 2018 with no safety concerns at current use levels.
Sustainability
Synthetic production avoids the ecological impact of rose cultivation (1kg rose oil requires 4 tons petals). Modern catalytic methods reduce solvent waste compared to traditional syntheses. Biotech routes using engineered yeast show promise for future sustainable production.
Explore (+)-cis-Rose oxide
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References
- Ohloff, G. (1994). Scent and Fragrances. Springer. ISBN 978-3-642-78426-8
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 4610-11-1Physical Properties
| Molecular Weight | 154.25 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 2.9🔬 PubChem |
| Boiling Point | 184 °C🔬 EPA CompTox |
| Vapor Pressure | 0.955 mmHg @ 25°C📊 OPERA |
| Flash Point | 66.8 °C🔬 EPA CompTox |
| Involatility Index | 0.0829💻 Calculated |
| log Kp (skin permeability) | -1.582💻 Calculated |
| SMILES | CC1CCOC(C1)C=C(C)C🔬 PubChem |
Volatility & Performance
| Fragrance Note | Top💻 Calculated |
| Volatility Class | Slow💻 Calculated |
| Persistence Score | 0.5 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | green• leffingwell |
| Functional Groups | etheralkene💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID50894739
Physical Properties
| Molecular Weight | 154.253 g/mol🔬 EPA CompTox |
| Density | 0.904 g/cm^3📊 OPERA |
| Boiling Point | 190.757 °C📊 OPERA |
| Melting Point | -28.712 °C📊 OPERA |
| Flash Point | 64.721 °C📊 OPERA |
| Refractive Index | 1.496 Dimensionless📊 OPERA |
| Molar Volume | 169.683 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 3.768 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 3.768 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 3.768 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 4.74 Log10 unitless📊 OPERA |
| Water Solubility | 0.006 mol/L📊 OPERA |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.746 mmHg📊 OPERA |
| Viscosity | 1.529 cP📊 OPERA |
| Surface Tension | 27.034 dyn/cm📊 OPERA |
| Thermal Conductivity | 119.265 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 9.23 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 49.593 cm^3/mol📊 OPERA |
| Polarizability | 19.66 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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