Carbamic acid, N,N-dimethyl-, 1-ethenyl-1,5-dimethyl-4-hexen-1-yl ester (CAS 67643-70-3) — Woody Middle to base Note Fragrance Ingredient

ByThe Good Scents
Woody · Musky

Carbamic acid, N,N-dimethyl-, 1-ethenyl-1,5-dimethyl-4-hexen-1-yl ester

CAS 67643-70-3

Origin
synthetic
Note
Middle to base
IFRA
Use with awareness
Data as of: Apr 2026

What Is Carbamic acid, N,N-dimethyl-, 1-ethenyl-1,5-dimethyl-4-hexen-1-yl ester?

Carbamic acid, N,N-dimethyl-, 1-ethenyl-1,5-dimethyl-4-hexen-1-yl ester is a synthetic fragrance ingredient used in modern perfumery. It’s found in some niche and designer fragrances, often as a modifier for woody or amber accords. This compound helps perfumers create unique scent profiles by adding subtle complexity. While not commonly recognized by name, it contributes to the depth and longevity of fragrances where it’s used.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
✓ Approved for use in fragrances
⚠ Limited safety data available
CAS
67643-70-3
Formula
Mixture
MW
Variable
Odor Family
Woody · Musky
Layer 1 · Enthusiast

What Does Carbamic acid, N,N-dimethyl-, 1-ethenyl-1,5-dimethyl-4-hexen-1-yl ester Smell Like?

This synthetic molecule presents a complex olfactory profile that evolves on the skin. Initially, it offers a fresh, slightly green top note with subtle fruity undertones. As it develops, it reveals a warm, woody heart with hints of ambery sweetness. The dry-down is characterized by a clean, musky base with excellent tenacity. The overall effect is subtle yet sophisticated, making it ideal for adding depth to modern fragrance compositions without overwhelming other notes.

Scent Profile
Layer 2

2D Molecular Structure

Carbamic acid, N,N-dimethyl-, 1-ethenyl-1,5-dimethyl-4-hexen-1-yl ester

SMILES: CN(C)C(=O)OC(C)(CCC=C(C)C)C=C

Chemistry, Properties & Perfumer Guide

The Chemistry

This carbamate ester belongs to the class of nitrogen-containing organic compounds. It’s synthesized through esterification reactions between the appropriate alcohol and carbamoyl chloride derivatives. The molecule features both a vinyl group and a dimethyl-substituted hexene moiety, which contribute to its unique volatility and olfactory properties. The ester linkage provides stability while allowing controlled release of the fragrance during wear.

Physical & Chemical Properties

Boiling PointNot available
DensityNot available

Perfumer Guide

Note Position
Middle to base
Volatility
Moderate (2-6 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Used as a modifier in woody accords
Functional Fragrances0.5-2%Up to 3%Adds subtle complexity

Classic Accords

Tip: Use sparingly to enhance woody bases without dominating the composition.

Alternatives & Comparisons

1
Amber Xtreme CAS 6790-58-5

A more powerful woody-amber material that can be used when greater projection is desired.

2
Vertofix Coeur CAS 68039-49-6

Offers similar woody characteristics with better stability in alkaline formulations.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

No specific IFRA restrictions currently apply to this material.

RIFM Assessment

Full RIFM safety assessment not yet available for this material.

Sustainability

As a synthetic material, this compound is produced through controlled chemical processes with minimal environmental impact compared to some natural alternatives. The production can be optimized for atom economy and energy efficiency, though specific lifecycle analysis data is not currently available for this particular molecule.

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References

    Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

    Report a data error

    Ingredient Data Sheet

    CAS 67643-70-3

    Physical Properties

    Molecular Weight225.33 g/mol🔬 PubChem
    LogP (Octanol-Water)3.3🔬 PubChem
    Boiling Point255 °C🔬 EPA CompTox
    Vapor Pressure0.0086 mmHg @ 25°C📊 OPERA
    Flash Point128 °C🔬 EPA CompTox
    Involatility Index0.0006💻 Calculated
    log Kp (skin permeability)-1.732💻 Calculated
    SMILESCC(=CCCC(C)(C=C)OC(=O)N(C)C)C🔬 PubChem

    Volatility & Performance

    Fragrance NoteHeart💻 Calculated
    Volatility ClassVery slow💻 Calculated
    Persistence Score4.2 / 5💻 Calculated

    Odor & Flavor

    Functional Groupsetheralkene💻 RDKit
    “This material finds use in various floral bases and specialties, and it is usually only a minor component of such products. It contributes power and radiation of the odor, natural warm greenness in the Rose-Geranium character, and it works well with the Rose oxides and related chemicals.”📖 Arctander
    Data Sources & Attribution
    Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

    Physicochemical Properties

    DTXSID: DTXSID30886334

    Physical Properties

    Molecular Weight 225.332 g/mol🔬 EPA CompTox
    Density 0.934 g/cm^3🔬 EPA CTX
    Boiling Point 270.821 °C📊 OPERA
    Melting Point 19.977 °C📊 OPERA
    Flash Point 128 °C🔬 EPA CTX
    Refractive Index 1.468 Dimensionless📊 OPERA
    Molar Volume 242.416 cm^3/mol📊 OPERA

    Partition & Solubility

    LogP (Octanol-Water) 4.3 Log10 unitless🔬 EPA CTX
    LogD (pH 5.5) 2.59 Log10 unitless📊 OPERA
    LogD (pH 7.4) 3.47 Log10 unitless📊 OPERA
    LogKoa (Octanol-Air) 6.75 Log10 unitless📊 OPERA
    Water Solubility 0 mol/L🔬 EPA CTX
    Henry's Law Constant 0 atm-m3/mole📊 OPERA

    Transport Properties

    Vapor Pressure 0.009 mmHg🔬 EPA CTX
    Viscosity 4.876 cP📊 OPERA
    Surface Tension 29.984 dyn/cm📊 OPERA

    Molecular Descriptors

    Topological Polar Surface Area 29.54 Ų💻 Computed
    H-Bond Donors 0 count💻 Computed
    H-Bond Acceptors 2 count💻 Computed
    Rotatable Bonds 5 count💻 Computed
    Aromatic Rings 0 count💻 Computed
    Molar Refractivity 67.364 cm^3/mol📊 OPERA
    Polarizability 26.705 Å^3📊 OPERA

    Data Sources:

    🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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