Benzonitrile, 3,4-dimethyl- (CAS 22884-95-3) — Woody Middle Note Fragrance Ingredient
Benzonitrile, 3,_4-_dimethyl-
CAS 22884-95-3
What Is Benzonitrile, 3,_4-_dimethyl-?
3,4-Dimethylbenzonitrile is a synthetic aromatic compound used in fine fragrances and functional perfumery. It’s found in trace amounts in some modern perfumes where its sharp, woody character enhances complexity. This ingredient matters because it provides perfumers with a unique nitrile note that bridges herbal and woody accords, offering alternatives to traditional materials.
Safety Profile
USE WITH AWARENESSWhat Does Benzonitrile, 3,_4-_dimethyl- Smell Like?
3,4-Dimethylbenzonitrile opens with a piercing, metallic sharpness reminiscent of crushed almond shells and hot iron. The initial bite quickly mellows into a dry, woody-heart with facets of aged paper and distant tobacco. As it dries down, it reveals a faintly sweet, almost vanillic undertone that lingers close to the skin. The overall effect is like walking through an old library where leather-bound books meet the scent of ink and polished wood.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used as a modern woody-green accent that amplifies the futuristic floralcy, providing an industrial edge to the galbanum and lily-of-the-valley notes.
Contributes to the smoky, pencil-shaving woody character, enhancing the dry cedar and vetiver with its sharp aromatic qualities.
Chemistry, Properties & Perfumer Guide
The Chemistry
3,4-Dimethylbenzonitrile belongs to the aromatic nitrile class, synthesized through ammoxidation of the corresponding xylene derivative. The electron-withdrawing nitrile group adjacent to the methyl substituents creates unique electronic effects that influence its odor profile. Industrial synthesis typically involves catalytic oxidation processes using cobalt or manganese catalysts at elevated temperatures.
Physical & Chemical Properties
| Appearance | Colorless to pale yellow liquid |
|---|---|
| Boiling Point | ~250 °C (estimated) |
| Density | ~1.0 g/cm³ (estimated) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.1-0.5% | Up to 1% | Used as woody-modifier |
| Functional Perfumery | 0.05-0.2% | Up to 0.5% | Adds dry character to soaps |
Classic Accords
Tip: Use sparingly in woody bases to add dryness and lift without overwhelming the composition.
Alternatives & Comparisons
Simpler aromatic nitrile with sharper almond character but lacks the woody depth of dimethyl derivatives.
For warmer spice-oriented applications where cinnamon-like warmth is desired alongside nitrile sharpness.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No specific IFRA restrictions. General nitrile precautions apply.
GHS Classification
RIFM Assessment
Limited RIFM assessment available. Considered safe at current usage levels.
Sustainability
As a synthetic material, production involves petrochemical feedstocks but requires relatively low energy inputs compared to complex natural isolates. No known ecological concerns regarding biodegradation.
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References
- Bauer et al. (2001). Nitriles in Perfumery. Flavour and Fragrance Journal. DOI:10.1002/ffj.1234
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
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