4-Cyclopentadecen-1-one, (Z)- (CAS 14595-54-1) — Musky Base Note Fragrance Ingredient
4-Cyclopentadecen-1-one, (Z)-
CAS 14595-54-1
What Is 4-Cyclopentadecen-1-one, (Z)-?
4-Cyclopentadecen-1-one, (Z)- is a synthetic musk used in high-end fragrances. Consumers encounter it in luxury perfumes and body care products where it provides a velvety, animalic depth. This ingredient matters because it mimics rare natural musks without ethical concerns, offering perfumers a sustainable alternative for creating sensual, long-lasting scent profiles.
Safety Profile
USE WITH AWARENESSWhat Does 4-Cyclopentadecen-1-one, (Z)- Smell Like?
A warm, intimate musk with the supple texture of sun-warmed suede. Opens with a faintly metallic edge like distant lightning, quickly melting into a skin-like intimacy. The dry-down reveals a narcotic sweetness akin to human pheromones, with lingering traces of clean linen and warm amber. Exceptionally tenacious, it behaves like a molecular velcro – enhancing other notes while maintaining its distinctive character for 24+ hours.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used here to create the infamous ‘dirty clean’ effect – amplifying the animalic warmth while providing a smooth, modern musk foundation that prevents the composition from becoming overwhelming.
Provides the velvety underpinning to this opulent fragrance, blending seamlessly with oud and berries to create a regal, enveloping muskiness.
2D Molecular Structure
SMILES: O=C1CCCCCCCCCC\C=C/CC1
Chemistry, Properties & Perfumer Guide
The Chemistry
A macrocyclic ketone belonging to the class of synthetic musks. Unlike nitro or polycyclic musks, these compounds more closely resemble natural musk ketones in structure. Typically synthesized through ring-closing metathesis of long-chain dienes followed by selective hydrogenation. The (Z)-configuration is crucial for optimal odor properties, with the double bond introducing conformational rigidity that enhances muskiness.
Physical & Chemical Properties
| Molecular Weight | 224.38 g/mol |
|---|---|
| Boiling Point | ~300 °C (estimated) |
| LogP | ~6.2 (estimated) |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 0.5-3% | Up to 5% | Foundation for oriental and woody compositions |
| Functional Fragrances | 0.1-0.5% | Up to 1% | Fabric softeners and detergents |
| Home Fragrance | 0.01-0.1% | Up to 0.3% | Candles and diffusers |
Classic Accords
Tip: Use with ionones to create a seamless musk-floral transition.
Alternatives & Comparisons
When a cleaner, more laundry-like musk is desired. Less animalic but similar tenacity and blending properties.
For ultra-premium applications requiring exceptional diffusion and natural feel. More expensive but superior odor profile.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
Not currently restricted by IFRA. Listed as safe when used within industry standards.
RIFM Assessment
RIFM assessment completed – no significant safety concerns at current usage levels.
Sustainability
As a synthetic musk, this compound avoids the ethical and conservation issues associated with natural musk deer harvesting. Production typically involves petrochemical feedstocks, though emerging bio-based synthesis routes show promise. Unlike some older musks, it demonstrates good biodegradability and low aquatic toxicity.
Explore 4-Cyclopentadecen-1-one, (Z)-
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References
- IFRA Standards Library IFRA 49th Amendment
- PubChem Compound Summary CID 14595-54-1
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 14595-54-1Physical Properties
| Molecular Weight | 222.37 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 5.2🔬 PubChem |
| Boiling Point | 285 °C🔬 EPA CompTox |
| Vapor Pressure | 0.0014 mmHg @ 25°C📊 OPERA |
| Flash Point | 152 °C🔬 EPA CompTox |
| Involatility Index | 0.0001💻 Calculated |
| log Kp (skin permeability) | -0.364💻 Calculated |
| SMILES | C1CCCCCC(=O)CCC=CCCCC1🔬 PubChem |
Volatility & Performance
| Fragrance Note | Base💻 Calculated |
| Volatility Class | Very slow💻 Calculated |
| Persistence Score | 7.1 / 5💻 Calculated |
Odor & Flavor
| Functional Groups | ketonealkene💻 RDKit |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID0051730
Physical Properties
| Molecular Weight | 222.372 g/mol🔬 EPA CompTox |
| Density | 0.941 g/cm^3🔬 EPA CTX |
| Boiling Point | 285 °C🔬 EPA CTX |
| Melting Point | 46.761 °C📊 OPERA |
| Flash Point | 152 °C🔬 EPA CTX |
| Refractive Index | 1.451 Dimensionless📊 OPERA |
| Molar Volume | 255.889 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 5.154 Log10 unitless🔬 EPA CTX |
| LogD (pH 5.5) | 5.095 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 5.095 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 7.8 Log10 unitless📊 OPERA |
| Water Solubility | 0 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.001 mmHg🔬 EPA CTX |
| Viscosity | 4.69 cP📊 OPERA |
| Surface Tension | 30.097 dyn/cm📊 OPERA |
| Thermal Conductivity | 145.228 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 17.07 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 0 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 68.91 cm^3/mol📊 OPERA |
| Polarizability | 27.318 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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