4′-tert-Butyl-2′,6′-dimethylacetophenone (CAS 2040-10-0) — Woody Base Note Fragrance Ingredient
4'-tert-Butyl-2',6'-dimethylacetophenone
CAS 2040-10-0
What Is 4'-tert-Butyl-2',6'-dimethylacetophenone?
4′-tert-Butyl-2′,6′-dimethylacetophenone is a synthetic fragrance ingredient used to add woody, ambery notes to perfumes. It’s found in niche and designer fragrances, particularly those aiming for a modern interpretation of classic woody accords. This molecule matters because it offers perfumers a stable, long-lasting alternative to natural materials, with consistent quality and performance in formulations.
Safety Profile
GENERALLY SAFEWhat Does 4'-tert-Butyl-2',6'-dimethylacetophenone Smell Like?
This synthetic molecule delivers a dry, woody character with subtle ambery undertones. Imagine the scent of sun-warmed cedar planks with a whisper of vanilla-like sweetness. The initial impression is crisp and slightly sharp, evolving into a smoother, more rounded profile over time. In the dry-down, it behaves like a quiet foundation note, adding depth without overpowering other elements.
Chemistry, Properties & Perfumer Guide
The Chemistry
4′-tert-Butyl-2′,6′-dimethylacetophenone belongs to the alkylated acetophenone class, synthesized through Friedel-Crafts acylation. Its structure features a tert-butyl group and two methyl groups on the aromatic ring, which influence its volatility and odor characteristics. The molecule’s stability comes from its symmetrical substitution pattern, making it resistant to oxidation and degradation in formulations.
Physical & Chemical Properties
| Boiling Point | Not available |
|---|---|
| Density | Not available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-5% | Up to 10% | Used as a woody-amber base note |
| Home Care | 0.5-2% | Up to 5% | Provides long-lasting woody character |
Classic Accords
Tip: Use in small amounts to anchor floral compositions without dominating.
Alternatives & Comparisons
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No IFRA restrictions currently apply.
RIFM Assessment
No specific RIFM assessment found for this material.
Sustainability
As a synthetic material, this ingredient avoids agricultural impacts but depends on petrochemical feedstocks. Its production can be optimized for energy efficiency given its industrial synthesis route.
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