2,4,6-Trimethylcyclohex-3-enecarbaldehyde (CAS 1423-46-7) — Green Top to middle Note Fragrance Ingredient
2,4,6-Trimethylcyclohex-3-enecarbaldehyde
CAS 1423-46-7
What Is 2,4,6-Trimethylcyclohex-3-enecarbaldehyde?
2,4,6-Trimethylcyclohex-3-enecarbaldehyde is a synthetic fragrance ingredient used in modern perfumery to create fresh, green, and slightly woody aromas. It’s often found in fine fragrances, body care products, and household cleaners. This aldehyde is valued for its ability to add a crisp, natural character to floral and citrus compositions, enhancing their vibrancy and longevity.
Safety Profile
USE WITH AWARENESSWhat Does 2,4,6-Trimethylcyclohex-3-enecarbaldehyde Smell Like?
2,4,6-Trimethylcyclohex-3-enecarbaldehyde opens with a sharp, green freshness reminiscent of crushed leaves and freshly cut grass. As it evolves, it reveals a slightly woody undertone with a hint of citrusy brightness, like a sunlit forest after rain. The dry-down is clean and slightly herbaceous, leaving a subtle, natural impression that blends well with floral and woody notes.
In Famous Fragrances
Fragrance associations may not reflect actual formulations.
Used to enhance the fresh, green tea character, adding a crisp, natural edge to the citrus and floral notes.
Contributes to the vibrant, green accord that mimics the lush vegetation along the Nile.
Adds a fresh, green facet to the citrus top notes, enhancing the overall brightness.
Used to amplify the aquatic freshness, providing a green, natural undertone.
Enhances the green, galbanum note, adding depth and complexity to the floral heart.
2D Molecular Structure
SMILES: CC1CC(C)=CC(C)C1C=O
Chemistry, Properties & Perfumer Guide
The Chemistry
2,4,6-Trimethylcyclohex-3-enecarbaldehyde is a synthetic aldehyde with a cyclohexene ring structure. It is typically synthesized through the Diels-Alder reaction or by oxidation of corresponding alcohols. Its molecular structure features a conjugated system that contributes to its green, fresh odor profile. The compound is chiral, and its enantiomers may exhibit slightly different olfactory characteristics.
Physical & Chemical Properties
| Boiling Point | Not available |
|---|---|
| Density | Not available |
| Vapor Pressure | Not available |
| Solubility | Not available |
Perfumer Guide
| Application | Typical % | Range | Notes |
|---|---|---|---|
| Fine Fragrance | 1-5% | Up to 10% | Adds freshness and green character |
| Body Care | 0.5-2% | Up to 5% | Enhances clean, natural scents |
| Household Cleaners | 0.1-1% | Up to 3% | Provides a fresh, green note |
Classic Accords
Tip: Use in small amounts to avoid overpowering other notes; works well with citrus and floral ingredients.
Alternatives & Comparisons
Provides a fresh, floral-green note with better stability in formulations.
Safety, Regulatory & Sustainability
⚠ Regulatory Disclaimer
General reference only. Consult current IFRA Standards Library before formulating.
IFRA Status
No specific restrictions under IFRA standards.
GHS Classification
RIFM Assessment
RIFM has assessed this ingredient as safe for use in current practices.
Sustainability
As a synthetic ingredient, 2,4,6-Trimethylcyclohex-3-enecarbaldehyde is produced in controlled laboratory settings, reducing the environmental impact associated with natural extraction. Its synthesis can be optimized for minimal waste and energy use, making it a sustainable choice for modern perfumery.
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References
- PubChem. 2,4,6-Trimethylcyclohex-3-enecarbaldehyde. PubChem
- IFRA Standards Library. IFRA
- RIFM Safety Assessment. RIFM
Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.
Report a data errorIngredient Data Sheet
CAS 1423-46-7Physical Properties
| Molecular Weight | 152.23 g/mol🔬 PubChem |
| LogP (Octanol-Water) | 1.9🔬 PubChem |
| Boiling Point | 214 °C🔬 EPA CompTox |
| Vapor Pressure | 0.39 mmHg @ 25°C📊 OPERA |
| Flash Point | 66 °C🔬 EPA CompTox |
| Involatility Index | 0.0341💻 Calculated |
| log Kp (skin permeability) | -2.28💻 Calculated |
| SMILES | CC1CC(=CC(C1C=O)C)C🔬 PubChem |
Volatility & Performance
| Fragrance Note | Top💻 Calculated |
| Volatility Class | Slow💻 Calculated |
| Persistence Score | 0.6 / 5💻 Calculated |
Odor & Flavor
| Primary Descriptors | greenwoody• leffingwell |
| Functional Groups | aldehydealkene💻 RDKit |
Regulatory Status
| IFRA Listed | Yes — see IFRA Standards for category limits⚖️ IFRA 51 |
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.
Physicochemical Properties
DTXSID: DTXSID5052678
Physical Properties
| Molecular Weight | 152.237 g/mol🔬 EPA CompTox |
| Density | 0.92 g/cm^3🔬 EPA CTX |
| Boiling Point | 203 °C🔬 EPA CTX |
| Melting Point | -0.36 °C📊 OPERA |
| Flash Point | 66 °C🔬 EPA CTX |
| Refractive Index | 1.496 Dimensionless📊 OPERA |
| Molar Volume | 164.291 cm^3/mol📊 OPERA |
Partition & Solubility
| LogP (Octanol-Water) | 2.964 Log10 unitless📊 OPERA |
| LogD (pH 5.5) | 2.964 Log10 unitless📊 OPERA |
| LogD (pH 7.4) | 2.964 Log10 unitless📊 OPERA |
| LogKoa (Octanol-Air) | 4.83 Log10 unitless📊 OPERA |
| Water Solubility | 0.014 mol/L🔬 EPA CTX |
| Henry's Law Constant | 0 atm-m3/mole📊 OPERA |
Transport Properties
| Vapor Pressure | 0.506 mmHg🔬 EPA CTX |
| Viscosity | 2.758 cP📊 OPERA |
| Surface Tension | 30.985 dyn/cm📊 OPERA |
| Thermal Conductivity | 122.261 mW/(m*K)📊 OPERA |
Molecular Descriptors
| Topological Polar Surface Area | 17.07 Ų💻 Computed |
| H-Bond Donors | 0 count💻 Computed |
| H-Bond Acceptors | 1 count💻 Computed |
| Rotatable Bonds | 1 count💻 Computed |
| Aromatic Rings | 0 count💻 Computed |
| Molar Refractivity | 48.003 cm^3/mol📊 OPERA |
| Polarizability | 19.03 Å^3📊 OPERA |
Data Sources:
🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.
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