1-(2,4,4-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one (CAS 70266-48-7) — Woody Middle Note Fragrance Ingredient

ByThe Good Scents
Woody · Balsamic

1-(2,4,4-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one

CAS 70266-48-7

Origin
synthetic
Note
Middle
IFRA
Generally safe
Data as of: Apr 2026

What Is 1-(2,4,4-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one?

1-(2,4,4-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one is a synthetic fragrance ingredient used to add woody, amber-like notes to perfumes. It’s commonly found in modern fragrances aiming for a warm, slightly spicy character. This molecule matters because it provides stability and longevity to fragrance compositions, making scents last longer on skin while contributing a sophisticated depth.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ Safe in regulated products
⚠ Check for individual sensitivity
CAS
70266-48-7
Formula
Mixture
MW
Variable
Odor Family
Woody · Balsamic
Layer 1 · Enthusiast

What Does 1-(2,4,4-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one Smell Like?

This molecule offers a complex olfactory profile starting with a sharp, woody-green opening that evolves into a warm, ambery heart. The dry-down reveals a subtle leathery nuance, resembling sun-warmed cedarwood with a whisper of tobacco. Over time, it behaves like a slow-burning incense stick—initially bright, then deepening into resinous warmth that lingers close to the skin.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Santal 33(Le Labo, 2011)

Used here to amplify the woody-amber backbone, providing the signature pencil shavings effect that makes this fragrance instantly recognizable.

Terre d'Hermès(Hermès, 2006)

Contributes to the flinty mineral character, blending with vetiver to create an impression of sun-baked earth.

Layer 2

2D Molecular Structure

1-(2,4,4-Trimethyl-1-cyclohexen-1-yl)-2-buten-1-one

SMILES: CC=CC(=O)C1=C(C)CC(C)(C)CC1

Chemistry, Properties & Perfumer Guide

The Chemistry

This ketone belongs to the cyclohexene derivative family, synthesized through controlled oxidation reactions. The trimethylcyclohexene structure provides excellent stability against photodegradation. Its conjugated double bond system contributes to both tenacity and diffusion properties in fragrance applications. The molecular geometry creates specific receptor interactions that humans perceive as warm woody-amber notes.

Physical & Chemical Properties

Molecular Weight192.3 g/mol
Boiling Point~250 °C (estimated)
XLogP4.1 (estimated)

Perfumer Guide

Note Position
Middle
Volatility
Moderate (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-3%Up to 5%Adds woody depth
Home Fragrance0.5-2%Up to 3%Provides warmth

Classic Accords

Tip: Use with citrus top notes to prevent the woody character from becoming too heavy.

Alternatives & Comparisons

1
Iso E Super CAS 54464-57-2

When a cleaner, more diffusive woody note is desired without the amber nuances.

2
Norlimbanol CAS 70788-30-6

For stronger woody impact with more pronounced cedar character.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted by IFRA. Listed on the Transparency List.

RIFM Assessment

RIFM has conducted safety assessment confirming safe use at current levels.

Sustainability

As a synthetic material, this ingredient avoids natural resource depletion. Modern manufacturing processes minimize environmental impact through efficient catalysis and solvent recovery systems. The long-lasting nature reduces need for frequent reapplication, indirectly supporting sustainability.

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References

  1. PubChem Compound Summary CID 70266487
  2. IFRA Transparency List Ingredient 70266-48-7

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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Ingredient Data Sheet

CAS 70266-48-7

Regulatory Status

IFRA ListedYes — see IFRA Standards for category limits⚖️ IFRA 51
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

Physicochemical Properties

DTXSID: DTXSID501537970

Physical Properties

Molecular Weight 192.302 g/mol🔬 EPA CompTox

Partition & Solubility

LogP (Octanol-Water) 3.658 dimensionless💻 Computed

Molecular Descriptors

Topological Polar Surface Area 17.07 Ų💻 Computed
H-Bond Donors 0 count💻 Computed
H-Bond Acceptors 1 count💻 Computed
Rotatable Bonds 2 count💻 Computed
Aromatic Rings 0 count💻 Computed

Data Sources:

🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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