1-(1,2,3,4,6,7,8,8a-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one (CAS 68155-67-9) — Musky Base Note Fragrance Ingredient

ByThe Good Scents
Musky · Woody

1-(1,2,3,4,6,7,8,8a-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one

CAS 68155-67-9

Origin
synthetic
Note
Base
IFRA
Use with awareness
Data as of: Apr 2026

What Is 1-(1,2,3,4,6,7,8,8a-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one?

This synthetic musk is found in laundry detergents and long-lasting perfumes. It provides a clean, powdery foundation that helps other fragrance notes persist through wear. As a modern musk alternative, it avoids animal-derived ingredients while delivering similar olfactory effects.

Safety Profile

USE WITH AWARENESS
Generally safeUse with awarenessProfessional use
✓ IFRA-approved for most applications
⚠ Potential bioaccumulation concerns
CAS
68155-67-9
Formula
Mixture
MW
Variable
Odor Family
Musky · Woody
Layer 1 · Enthusiast

What Does 1-(1,2,3,4,6,7,8,8a-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one Smell Like?

A warm, diffusive musk with pronounced powdery character reminiscent of freshly laundered cotton. The initial impression is slightly metallic, evolving into clean skin-like tonality. Unlike animal musks, it lacks the urinous facets, instead presenting a rounded soapiness that lingers tenaciously on fabrics.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Clean Reserve Warm Cotton(Clean, 2015)

Used as the musk backbone to create a hyper-realistic laundry effect, blending with aldehydes for crispness.

Layer 2

2D Molecular Structure

1-(2,3,8,8-tetramethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl)ethan-1-one

SMILES: CC1CC2=CCCC(C)(C)C2CC1(C)C(C)=O

Chemistry, Properties & Perfumer Guide

The Chemistry

A tetralin derivative musk belonging to the polycyclic musk class. Synthesized via Friedel-Crafts acylation of tetramethyltetralin. Unlike nitro musks, this structure avoids phototoxicity concerns while maintaining excellent substantivity on textiles.

Physical & Chemical Properties

Molecular Weight262.4 g/mol
LogP5.2

Perfumer Guide

Note Position
Base
Volatility
Very low (days)
Blending
Good
ApplicationTypical %RangeNotes
Laundry Care0.1-0.5%Up to 1%Provides lasting freshness
Fabric Softeners0.05-0.2%Up to 0.3%Enhances clean perception

Classic Accords

Tip: Use with white musks to prevent excessive powderiness.

Alternatives & Comparisons

1
Galaxolide CAS 1222-05-5

When a brighter, less powdery musk effect is desired.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not restricted under current IFRA standards (Amendment 49).

RIFM Assessment

RIFM assessment complete – safe at current usage levels.

Sustainability

Synthetic production avoids wildlife harvesting. Being non-biodegradable, proper wastewater treatment is essential to prevent environmental persistence.

Explore 1-(1,2,3,4,6,7,8,8a-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one

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References

  1. IFRA Standards Library IFRA 49
  2. PubChem Compound Summary CID N/A

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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Ingredient Data Sheet

CAS 68155-67-9

Physical Properties

Molecular Weight234.38 g/mol🔬 PubChem
LogP (Octanol-Water)3.7🔬 PubChem
Boiling Point301 °C🔬 EPA CompTox
Vapor Pressure0.0021 mmHg @ 25°C📊 OPERA
Flash Point127.2 °C🔬 EPA CompTox
Involatility Index0.0002💻 Calculated
log Kp (skin permeability)-1.503💻 Calculated
SMILESCC1CC2=CCCC(C2CC1(C)C(=O)C)(C)C🔬 PubChem

Volatility & Performance

Fragrance NoteBase💻 Calculated
Volatility ClassVery slow💻 Calculated
Persistence Score5.7 / 5💻 Calculated

Odor & Flavor

Functional Groupsketonealkene💻 RDKit

Regulatory Status

IFRA ListedYes — see IFRA Standards for category limits⚖️ IFRA 51
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

Physicochemical Properties

DTXSID: DTXSID6041923

Physical Properties

Molecular Weight 234.383 g/mol🔬 EPA CompTox
Density 0.945 g/cm^3📊 OPERA
Boiling Point 294.963 °C📊 OPERA
Melting Point 40.621 °C📊 OPERA
Flash Point 135.011 °C📊 OPERA
Refractive Index 1.493 Dimensionless📊 OPERA
Molar Volume 247.089 cm^3/mol📊 OPERA

Partition & Solubility

LogP (Octanol-Water) 4.79 Log10 unitless📊 OPERA
LogD (pH 5.5) 4.79 Log10 unitless📊 OPERA
LogD (pH 7.4) 4.79 Log10 unitless📊 OPERA
LogKoa (Octanol-Air) 7.51 Log10 unitless📊 OPERA
Water Solubility 0 mol/L📊 OPERA
Henry's Law Constant 0 atm-m3/mole📊 OPERA

Transport Properties

Vapor Pressure 0.001 mmHg📊 OPERA
Surface Tension 32.062 dyn/cm📊 OPERA
Thermal Conductivity 115.238 mW/(m*K)📊 OPERA

Molecular Descriptors

Topological Polar Surface Area 17.07 Ų💻 Computed
H-Bond Donors 0 count💻 Computed
H-Bond Acceptors 1 count💻 Computed
Rotatable Bonds 1 count💻 Computed
Aromatic Rings 0 count💻 Computed
Molar Refractivity 71.809 cm^3/mol📊 OPERA
Polarizability 28.467 Å^3📊 OPERA

Data Sources:

🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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